Author: The Crit Lab

On Friday 6, Jorge Blazquez-Prieto defended his PhD thesis. It was a great presentation including three outstanding works:

Blázquez-Prieto J, López-Alonso I, Amado-Rodríguez L, Batalla-Solís E, González-López A, Albaiceta GM. Exposure to mechanical ventilation promotes tolerance to ventilator-induced lung injury by Ccl3 downregulation. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L847-56.

Blázquez-Prieto J, López-Alonso I, Amado-Rodríguez L, Huidobro C, González-López A, Kuebler WM, Albaiceta GM. Impaired lung repair during neutropenia can be reverted by matrix metalloproteinase-9. Thorax. 2018 Apr;73(4):321-330.

Blázquez-Prieto J, López-Alonso I, Huidobro C, Albaiceta GM. The Emerging Role of Neutrophils in Repair after Acute Lung Injury. Am J Respir Cell Mol Biol. 2018 Apr 30.

Congrats, Jorge!

We have been in the Spanish Society of Intensive Care (SEMICYUC) annual conference. Here, we presented some of our new results coming from clinical research.

Laura Amado gave a talk on ultraprotective ventilation. This session focused in ARDS management was a great success. Congrats to all the speakers!

And Cecilia del Busto presented our data on frailty, mechanical ventilation and postICU outcomes. It’s a nice way to get feedback for the future paper. And more complex analyses are on the way.

Our clinical research lines, with old-fashioned physiological endpoints, are alive and well. If you want to collaborate, please contact us.

This year’s ATS Conference has been an great experience. We have presented some new data, learned a few things and shared a lot of discussions with amazing people. The abstracts have been published in the blue journal.

Now, we’re back in the lab, trying to move forward, one step at a time. And thinking in the next meeting!

Our review on the role of neutrophils in lung repair has been published in the American Journal of Respiratory Cell and Molecular Biology. After our work in neutropenic patients, we started to study their role after the initial phases of damage.

From the abstract:

There is emerging evidence that neutrophils not only contribute to that early damage, but also orchestrate later repair.  This article reviews the effects of neutrophils in repair after acute lung injury, focusing on their role as biovectors for proteases and other molecules involved in tissue remodeling.

You can find the manuscript here.

Join us at ESICM Lives Forum, focused on Respiratory Monitoring. We will discuss different strategies to set PEEP. A classic discussion within an amazing scientific programme.